Results between the two sites in the intermediate and high probability groups were statistically different.Ī subsequent review and meta-analysis of the 4Ts scoring system for HIT found that patients in the low-risk group had a negative predictive value of 0.998, irrespective of type of clinician, prevalence of HIT, or patient population.HIT usually occurs after you are treated with heparin. One of the four components of their scoring system, other causes for thrombocytopenia, is subjective. Heparin-induced thrombocytopenia (HIT) is a condition that causes a decrease of platelets in the blood.
The study used two different tests to diagnose HIT, depending on the site.Scoring system criteria for HIT was slightly different between the two main sites.A positive heparin-induced platelet activation (HIPA) test in at least three of four donor platelets.A platelet serotonin release assay (SRA) and a PF4/polyanion-enzyme immunoassay (EIA) with ≥50% serotonin release and positive EIA, OR.Gold standard for diagnosis of HIT was either:.Study used ≤3 points to define low probability group (≤5%) for HIT, 4-5 points for intermediate and 6-8 points for high.Scoring system consisted of four criteria, each of which was worth 0, 1, or 2 points.The study prospectively applied previously developed scoring systems using various clinical features of HIT.Included patients being evaluated for thrombocytopenia or suspected HIT in two clinical settings: inpatients at Hamilton General Hospital (HGH) in Canada and various clinicians in a variety of healthcare settings in Germany and Austria.The 4Ts for the diagnosis of heparin-induced thrombocytopenia (HIT) is a tool developed to help clinicians rule out HIT in patients who develop thrombocytopenia in the clinical setting.
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